A recent study suggests that a fasting-mimicking diet (FMD) may be beneficial for individuals with Crohn's disease, leading to improved symptoms and biological indicators of the condition.
Short-Term Calorie Deficit May Be Beneficial
Research indicates that a short-term calorie deficit, specifically 700-1,100 calories per day for five consecutive days out of every month for three consecutive months, may provide significant improvement in physical symptoms and biological indicators of Crohn's disease.
Study Results
The study involved 97 participants with mild to moderate Crohn's disease from across the United States. The results showed that two-thirds of those who followed the fasting-mimicking diet experienced an improvement in their symptoms, compared to less than half of those in the control group.
Biological Indicators Improve
Participants who followed the fasting-mimicking diet also showed significant changes in biological indicators of disease, including reduced gut inflammation and lower levels of inflammatory molecules produced by immune cells. These findings suggest that the FMD may have a positive impact on the underlying causes of Crohn's disease.
Expert Insights
"We were very pleasantly surprised that the majority of patients seemed to benefit from this diet," said Sidhartha R. Sinha, MD, an assistant professor of gastroenterology and hepatology at Stanford University. "This study will give physicians evidence to support recommendations in an area that patients are very curious about."
While the results are promising, it's essential to note that a fasting-mimicking diet may not be suitable for everyone with Crohn's disease, particularly those who are at risk of malnutrition, weight loss, or dehydration. Consult with your healthcare provider before making any changes to your diet.
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